Bob Saget has died at age 65.

The comedian and Full House star was found dead Sunday in his Orlando, Florida hotel room, the Orange County Sheriff’s Office confirmed.

“Earlier today, deputies were called to the Ritz-Carlton Orlando, Grande Lakes for a call about an unresponsive man in a hotel room,” the sheriff’s office tweeted. “The man was identified as Robert Saget & pronounced deceased on scene. Detectives found no signs of foul play or drug use in this case.”

Saget, who just began his I Don’t Do Negative Tour, had been traveling across the country.

On Saturday night, he did a show at the Ponte Vedra Concert Hall in Jacksonville, Florida, and early Sunday morning tweeted: “Loved tonight’s show @PV_ConcertHall in Jacksonville. Appreciative audience. Thanks again to @RealTimWilkins for opening. I had no idea I did a 2 hr set tonight. I’m happily addicted again to this sh**. Check http://BobSaget.com for my dates in 2022.”

Saget was best known for playing the role of widowed dad-of-three Danny Tanner on the ABC sitcom Full House, which aired from 1987 to 1995. He reprised the role in Netflix’s reboot of the show, Fuller House, which ended its four season run in 2020.

Saget is also remembered for hosting America’s Funniest Home Videos from 1989 to 1997. Other memorable roles include voicing the older Ted Mosby on CBS’ How I Met Your Mother, playing a parody version of himself in HBO’s Entourage, and starring in the sitcoms Raising Dad and Surviving Suburbia.

While he became famous for his family-friendly TV roles, his stand-up comedy was decidedly more adult. His 2014 album That’s What I’m Talkin’ About was nominated for a Grammy Award for Best Comedy Album.

Saget is survived by his second wife, Kelly Rizzo, and his three daughters from his first marriage, to Sherri Kramer.